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 What Does EPI Suite ™ Do?
• The EPI (Estimation Programs Interface) EPI Suite™ is a Windows® based suite of physical/chemical property and environmental fate estimation models developed by the EPA’s Office of Pollution Prevention Toxics and Syracuse Research Corporation (SRC). EPI Suite uses a single input to run the following estimation models: KOWWIN™, AOPWIN™, HENRYWIN™, MPBPWIN™, BIOWIN™, BioHCWIN, PCKOCWIN™, WSKOWWIN™, WATERNT™, BCFWIN™, HYDROWIN™, KOAWIN and AEROWIN™, and the fate models STPWIN™, WVOLWIN™, and LEV3EPI™. EPI Suite was previously called EPIWIN.
• EPI Suite is a screening level tool and should not be used if representative measured values are available.
• A clear understanding of the estimation methods and their appropriate application is very important. Click on the Help tab in EPI Suite for information for the methods and models in EPI Suite.

How Do the Individual Models that Make up EPI Suite Work?
KOWWIN™: Estimates the log octanol-water partition coefficient, log KOW, of chemicals using an atom/fragment contribution method.
AOPWIN™: Estimates the gas-phase reaction rate for the reaction between the most prevalent atmospheric oxidant, hydroxyl radicals, and a chemical. Gas-phase ozone radical reaction rates are also estimated for olefins and acetylenes. In addition, AOPWIN™ informs the user if nitrate radical reaction will be important. Atmospheric half-lives for each chemical are automatically calculated using assumed average hydroxyl radical and ozone concentrations.
HENRYWIN™: Calculates the Henry’s Law constant (air/water partition coefficient) using both the group contribution and the bond contribution methods.
MPBPWIN™: Melting point, boiling point, and vapor pressure of organic chemicals are estimated using a combination of techniques.  Included is the subcooled liquid vapor presssure, which is the vapor pressure a solid would have if it were liquid at room temperature.  It is important in fate modeling.
BIOWIN™: Estimates aerobic and anaerobic biodegradability of organic chemicals using 7 different models; two of these are the original Biodegradation Probability Program (BPP™).  The seventh and newest model estimates anaerobic biodegradation potential.
BioHCWIN: Estimates biodegradation half-life for compounds containing only carbon and hydrogen (i.e. hydrocarbons).
PCKOCWIN™: The ability of a chemical to sorb to soil and sediment, its soil adsorption coefficient (Koc), is estimated by this program. EPI's Koc estimations are based on the Sabljic molecular connectivity method with improved correction factors.
WSKOWWIN™: Estimates an octanol-water partition coefficient using the algorithms in the KOWWIN™ program and estimates a chemical’s water solubility from this value. This method uses correction factors to modify the water solubility estimate based on regression against log Kow.
WATERNT™: Estimates water solubility directly using a "fragment constant" method similar to that used in the KOWWIN™ model.
HYDROWIN™: Acid- and base-catalyzed hydrolysis constants for specific organic classes are estimated by HYDROWIN™. A chemical’s hydrolytic half-life under typical environmental conditions is also determined. Neutral hydrolysis rates are currently not estimated.
BCFWIN™: This program calculates the BioConcentration Factor and its logarithm from the log Kow. The methodology is analogous to that for WSKOWWIN™. Both are based on log Kow and correction factors.
KOAWIN: KOA is the octanol/air partition coefficient and has multiple uses in chemical assessment.  The model estimates KOA using the ratio of the octanol/water partition coefficient (KOW) from KOWWIN™, and the dimensionless Henry's Law constant (KAW) from HENRYWIN™.

AEROWIN™: Estimates the fraction of airborne substance sorbed to airborne particulates, i.e. the parameter phi (φ), using three different methods.  AEROWIN™ results are also displayed with AOPWIN™ output as an aid in interpretation of the latter.
WVOLWIN™: Estimates the rate of volatilization of a chemical from rivers and lakes; calculates the half-life for these two processes from their rates. The model makes certain default assumptions-water body depth; wind velocity; etc.
STPWIN™: Using several outputs from EPI Suite™, this program predicts the removal of a chemical in a Sewage Treatment Plant; values are given for the total removal and three contributing processes (biodegradation, sorption to sludge, and stripping to air.) for a standard system and set of operating conditions.
LEV3EPI™: This level III fugacity model predicts partitioning of chemicals between air, soil, sediment, and water under steady state conditions for a default model "environment"; various defaults can be changed by the user.

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